To date, loss of PTEN expression is only marginally correlated with up-regulation of PD-L1 on the membrane surface of tumor cells; in fact, PTEN abrogation often caused alteration in the tumor microenvironment, with increase of a non-inflamed tumor as a consequence of the release of anti-inflammatory cytokines and significant reduction of T-cell activity. This evidence concerns the gene CD274 and neoplasm.