GSTP1 and cancer: In support of these findings, our present results indicate that this tumorigenic capacity could likely be associated to the modulation of the expression of certain cancer-associated genes, in that the PCR-based array implemented herein to analyze the response of LNCaP cells to EN2 treatment revealed a relevant modulation of a discrete number of genes, including the upregulation of PSTGS1 and EGR3 and the downregulation of GSTP1. It is worth noting that both upregulated genes have been clearly shown to be involved in the association between inflammation and cancer [43,44].