In particular, treatment with exogenous EN2 protein elicited an increase in the proliferation capacity of the PCa cell lines LNCaP and PC3, an increase in the capacity to migrate of normal-like RWPE-1 and PC3 PCa cells and an increase in PSA secretion from LNCaP cells, which are, all of them, parameters directly associated to the tumorigenic capacity of these cells [38]. Here, EN2 is linked to posterior cortical atrophy.