In particular, RBM20 is responsible for alternative splicing within the I-band of TTN pre-mRNA (i.e., TTN central region with the most frequent events of differential alternative splicing), and mutations in the protein have been shown to result in the expression of large and highly compliant TTN isoforms, suggested to cause dilated cardiomyopathy [87]. This evidence concerns the gene TTN and dilated cardiomyopathy.