Although several recent studies have identified hypoalbuminemia as an independent predictor of mortality in CVD[20] (i.e., HF,[21–23] myocardial infarction,[24–26] or hemodialysis[27–29]), albumin was not included in most of the risk scores for mortality in CVD.[30–35] The insufficient recognition of albumin as a risk factor for mortality may be due to the strong interaction with other risk factors (i.e., hemoglobin and body weight) or missing values in previous observational studies due to the low attention to its risk. The gene discussed is ALB; the disease is hydrops fetalis.