Nowadays, cognitive dysfunction in NPSLE is associated with the presence in serum and CSF of antiphospholipid antibodies and anti-NMDA receptor subunit NR2A (anti-NR2A) antibodies levels, in addition to disease activity, glucocorticoids use, hypertension [3, 19, 25], and seizures [26]. This evidence concerns the gene GRIN2A and hypertensive disorder.