There were some reports about cystic contents of brain tumor and VEGF.5, 6, 17, 18 Cysts of metastatic and primary brain tumors including glioblastoma, protoplasmatic astrocytoma, pilocytic astrocytoma, ependymoma, meningioma, and craniopharyngiomas expressed high level of VEGF, and that was not reflected on serum level of VEGF. This evidence concerns the gene VEGFA and pilocytic astrocytoma.