There are other syndromes involving mineralocorticoid excess with low renin concentrations such as Cushing’s syndrome, glucocorticoid/cortisol resistance, apparent mineralocorticoid excess syndrome, excess licorice or carbenoxolone, congenital adrenal hyperplasia (11 beta- and 17 alpha-hydroxylase deficiencies), 11-deoxycorticosterone (DOC), 18-hydroxy-DOC excess, Geller syndrome, Gordon’s syndrome and Liddle’s syndrome which have more specific clinical findings and clues to identify patients with hypertension [6]. The gene discussed is REN; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.