Consensus clinical genetic testing guidelines include PC as a component tumor for seven of the confirmed PC genes in this study (BRCA1/2, MSH2, MSH6, ATM, PALB2, and CDKN2A).27, -29 Clinical histories of patients with mutations in these genes were evaluated to determine whether the respective genetic testing criteria were met (Table 5). This evidence concerns the gene MSH6 and neoplasm.