PNPLA3 and frontotemporal dementia: Notably, expression of acyl‐coenzyme A:cholesterol acyltransferase 1 (ACAT1) and Niemann‐Pick disease, type C intracellular cholesterol transporter 1 (NPC1) was profoundly down‐regulated (P < 0.01) in primary HSCs carrying the PNPLA3 variant, thus supporting that augmented FC content might result from decreased esterification to cholesterol esters (CEs) (Supporting Fig. S1).