Notably, expression of acyl‐coenzyme A:cholesterol acyltransferase 1 (ACAT1) and Niemann‐Pick disease, type C intracellular cholesterol transporter 1 (NPC1) was profoundly down‐regulated (P < 0.01) in primary HSCs carrying the PNPLA3 variant, thus supporting that augmented FC content might result from decreased esterification to cholesterol esters (CEs) (Supporting Fig. S1). This evidence concerns the gene NPC1 and frontotemporal dementia.