Analogously, it has been shown that PD-related proteins, such as α-synuclein, Parkin, and protein deglycase (DJ-1), promote ER–MT connections (Cali et al., 2012, 2013; Ottolini et al., 2013; Guardia-Laguarta et al., 2014). This evidence concerns the gene PRKN and Parkinson disease.