Previous data have shown that CD44 over-expression caused a significant up-regulation of the mesenchymal markers N-cadherin and Vimentin with a concomitant down-regulation of the epithelial markers E-cadherin and Claudin 7 in PA1 and SKOV3 ovarian cancer cells, indicating the possible involvement of CD44 in EMT (29). Here, CD44 is linked to ovarian carcinoma.