For instance, PVT1 forms a complex with EZH2 and then recruits EZH2 to the promoter regions of miR-195 and miR-200b, increases the trimethylation of histone H3K27, and downregulates the levels of miR-195 and miR-200b in cervical cancer (9, 41). Here, EZH2 is linked to cervical cancer.