Knocking down either Myc or PVT1 decreases proliferation of Myc/PVT1/Ccdc26/Gsdmc mutant tumor cells to the same extent as knocking down both PVT1 and Myc, thus suggesting the presence of a common oncogenic pathway shared by Myc and PVT1 in tumor initiation (64). This evidence concerns the gene CCDC26 and neoplasm.