MTHFR and coronary artery disorder: This linear relationship has, however, become a lot less straightforward in recent years, something that parallels the findings in the case of our 23-year-old patient with recurrent coronary events. Though studies have pointed towards those with homozygous thermolabile MTHFR variants being the most at risk for elevated homocysteine levels and ensuing CAD, others such as Naka et.