While both mutations cause multiple health issues, C677T appears to have the strongest association with CAD. In C677T, the MTHFR nucleotide at position 677 in the gene has a thymine (T) group rather than the wild type cytosine (C) which, in turn, results in a valine amino acid rather than an alanine, with greatly reduced enzymatic activity. Individuals homozygous for the thermolabile enzyme variant have lower MTHFR activity than CC (normal) or even CT (heterozygous) individuals and are much more sensitive to decreased folate levels. Here, MTHFR is linked to coronary artery disorder.