We performed this retrospective study to identify individuals with hydralazine-induced lupus and to describe their clinical and serological outcomes over time. Common serologies seen in drug-induced lupus were evaluated, including anti-histone antibody and antinuclear antibody (ANA). Less frequent serologies such as anti-proteinase 3 (PR3), anti-myeloperoxidase (MPO) and anti-glomerular basement membrane (GBM) antibodies were also analyzed due to the higher percentage of our cohort having pulmonary renal manifestations. The gene discussed is MPO; the disease is systemic lupus erythematosus.