CDKN1C and Beckwith-Wiedemann syndrome: Consistent with its role in growth and development, maternally-inheritedloss-of-function variants in CDKN1C are found in approximately 5–10% of individuals with the “overgrowth” condition, Beckwith-Wiedemann Syndrome (BWS) (OMIM130650) (Eggermannet al., 2014).