Importantly, this metabolic shift was dependenton myosin 2 activity, and less-invasive cell types displayed smaller responses.Collectively then, the elevation in myosin 2–dependent metabolicplasticity observed in response to changes in the mechanical environment mightprovide a mechanism that allows certain cancer cell types to survive inunfamiliar tissues and to enhance their metastatic potential. This evidence concerns the gene MYH2 and cancer.