The injection of these CRC cell clones s.c into immunocompromised mice resulted in a small increase in tumor formation upon CTSD overexpression (Figure 2F, compare CTSD cl 1 and 2 to L1), while CTSD suppression in L1 expressing cells resulted in a marked reduction in tumorigenic capacity of these cells (Figure 2F and 2G, compare L1+shCTSD cl1 and cl2 to L1). The gene discussed is CTSD; the disease is neoplasm.