The frequency of virus-specific CD8+ T cells, however, was not affected by the presence of HCC as similar frequencies were observed in HD (HCC: Median: 6.4*10-3; IQR: 7.1*10-3; HD: Median: 9.2*10-3; IQR: 1.2*10-3). This evidence concerns the gene CD8A and hepatocellular carcinoma.