As expected, in HD, circulating MAGE-A-specific CD8+ T cells largely displayed a naïve CD45RA+CCR7+ phenotype suggesting that these cells have not been primed in vivo (% antigen-experienced MAGE-A-specific CD8+ T cells in HD: Median: 7.0%; IQR: 23.6%). This evidence concerns the gene CD8A and Huntington disease.