All tested RTKIs and TKIs at dose of 5 μM for 24 h induced COX-2 expression in at least one of the tested COX-2-expressing bladder cancer cell lines (5637, SW780, TCCSUP, K9TCC#1Lillie, K9TCC#2Dakota, and K9TCC#5Lilly) in vitro as shown in Figure 2. The gene discussed is PTGS2; the disease is urinary bladder cancer.