The contradictory results for CCNA2 and CHECK1 in the whole cohort/PTCL-NOS and ALK-negative ALCL subgroups are in agreement with theories that gene effects are dependent of the interaction of intracellular networks of molecules, cell connections, the microenvironment, and epigenetic factors [26]. The gene discussed is ALK; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.