Other medically important protozoans include Trichomonas, Giardia, Trypanosoma, Acanthamoeba, and Naegleria. MIF orthologs have been discovered in Trichomonas and Giardia. The structure of Giardia MIF has been solved with a characterization similar to human MIF, but its role in infection is not well-understood (59). The gene discussed is MIF; the disease is infection.