On the other hand, it is evident that macrophage- and fibroblast-like synoviocye (FLS)-derived inflammatory cytokines such as TNFα, IL-1, and IL-6 are abundant in RA synovial fluid and involved in joint inflammation and destruction as well, illustrated by high effectiveness of anti-cytokine therapies targeting TNFα and IL-6 in controlling disease activities (4, 5). Here, TNF is linked to rheumatoid arthritis.