In addition, Tie2-expressing monocytes/macrophages can trigger angiogenesis and vascular activation by inducing the expression of ICAM1 on the endothelium through interactions with its ligand, Ang2 (83, 129, 130), and several compounds that inhibit the Ang2-Tie2 axis are now being explored in the clinical setting for metastatic cancer including in the context of improving response to immune checkpoint inhibitors (131). Here, ANGPT2 is linked to metastatic malignant neoplasm.