ICAM1 and obesity due to melanocortin 4 receptor deficiency: For example, in lung (one of the most frequent sites of cancer metastasis), mouse models have shown that obesity impairs vascular homeostasis when adiponectin levels drop, characterized by an increase in the expression of luminal adhesions including ICAM1, VCAM1, and E-selectin, and a decrease in endothelial adhesions such as VE-cadherin (56).