While we found compelling evidence that BTLA expression is downregulated on Mtb-specific CD4 T cells in HIV-infected patients with active TB, we found no evidence that CTLA-4 and PD-1 are upregulated in Mtb-specific CD4 T cells in HIV-infected individuals, unlike previous studies that have reported upregulation of CTLA-4 and PD-1 on HIV-specific CD4 T cells in HIV-infected individuals (52). This evidence concerns the gene CTLA4 and tuberculosis.