IFNGR2 and Mendelian susceptibility to mycobacterial diseases: Mutations in 15 genes are currently known to cause MSMD, which include IL12RB1, IL12B, IFNGR1, IFNGR2, STAT1, CYBB, IRF8, TYK2, ISG15, RORC, IKBKG, SPPL2A, JAK1, IL12RB2, and IL23R (1, 11, 12).