In particular, we observed that the low-grade PC microenvironment was enriched with more immature NK cells, characterized by lower expression of CD16, KIR, LIR-1, and CD57 and higher expression of NKG2A, as compared to autologous PB (Figures 2A,C and Supplementary Figures 1, 2). This evidence concerns the gene LILRB1 and pachyonychia congenita.