With disease progression (high-grade PC tumors), we found that expression of activating NK cell receptors (including NKp30, DNAM-1, and CD16) was recovered, and the expression of inhibitory receptors (such as KIRs, LIR-1, and PD-1) increased together with the maturation state of NK cells. The gene discussed is CD226; the disease is pachyonychia congenita.