Indeed, PC tumor cells can develop different mechanisms of immune escape capable of suppressing the activity of the immune system, including induction of PD-1 expression on T cells and release of pro-tumoral/immunosuppressive cytokines (such as IL6, IL10, and TGF-beta1) that may either regulate tumor growth or modify the anti-tumor immune responses (10–12). Here, IL6 is linked to neoplasm.