Also, Chalah MA et al. found that the pro-inflammatory cytokines IL-6, TNF-α, and IFNγ are related to MS fatigue, which is one of the distinct symptoms that the MS patients are suffering from (67) T-bet is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, IFN-γ (68). This evidence concerns the gene TNF and myeloid sarcoma.