Notably, in vivo pharmacological inhibition of IL-6 effectively counteracts denervation-mediated muscle atrophy (Madaro et al., 2018) and accumulation of FAPs with hyper-activation of IL-6 signaling has also been found in mouse models of amyotrophic lateral sclerosis (ALS) (Contreras et al., 2016; Madaro et al., 2018). This evidence concerns the gene IL6 and amyotrophic lateral sclerosis.