TRPV1 and Fabry disease: At present, the mechanism by which TRPV1 leads to increased visceral sensitivity in patients with FD may be related to the following factors: (1) dephosphorylation of TRPV1 can desensitize visceral sensation, and it can restore sensitivity to capsaicin when TRPV1 is re-phosphorylated (Mandadi et al., 2004).