SB705498, a potent selective TRPV1 antagonist, can exert significant antitussive effects and reduce neurogenic inflammation by reducing the expression of potent TRPV1 antagonism, demonstrating superior efficacy and potency in SP and CGRP in a capsaicin-induced cough model of guinea pigs (Zhang et al., 2018). This evidence concerns the gene TRPV1 and Cough.