P2RX7 and neoplasm: Given the increasing importance of P2X7 in the regulation of cellular energy metabolism, either during physiological or tumor conditions (Amoroso et al., 2012; Savio et al., 2018), in the present work we have investigated by IC the effects of P2X7 activation in mice that underwent 7-days treatment with the best available selective and specific P2X7 agonist BzATP.