Tools developed to study the role of ADK in epilepsy, including transgenic mouse lines (Tronche et al., 1999; Boison et al., 2002; Fedele et al., 2004) and adenoassociated viral vectors that knockdown ADK specifically in neurons or astrocytes (Theofilas et al., 2011), should be very instructive in advancing our understanding of the role played by ADK in respiratory control and the hypoxic ventilatory response. This evidence concerns the gene ADK and epilepsy.