Aiming at further realizing the effect of CDK5 on BIN1/c-MYC interaction, we then detected its expression in NSCLC cell lines, and found that H460, H1299, H1975, and A549 cells showed high CDK5 expression, while PC9 and H1972 cells showed low CDK5 expression. The gene discussed is MYC; the disease is non-small cell lung carcinoma.