The literature suggests that Cav-1 isdownregulated in colon cancer, breast cancer, ovarian carcinoma, and soft tissue sarcomas,while increased expression was seen in ductal adenocarcinoma of the pancreas, prostatecancer, squamous cell carcinoma, glioblastoma, non-small cell lung carcinoma (NSCLC) andrenal cell carcinoma.136. The gene discussed is CAV1; the disease is non-small cell lung carcinoma.