Trisomy 8 (+8) is reported to be one of the more common numerical chromosome abnormalities in AML, with the occurrence of 9% of adult patients and classified as intermediate prognosis.1 Sole +8 AML is molecularly heterogeneous with mutations in RUNX1, ASXL1, IDH, DNMT3A, NPM1, and FLT3-ITD being the most frequent.1 The patient did have a detectable mutation in IDH1 specifically in addition to mutations in CEBPA and JAK-2 at a very low level. The gene discussed is NPM1; the disease is acute myeloid leukemia.