NQO1 and acute myeloid leukemia: A high frequency of NAD(P)H: quinone oxidoreductase 1 (NQO1)C(609)T germline polymorphism in myelodysplastic syndrome/AML with trisomy 8 have been reported.12 NAD(P)H: quinone oxidoreductase 1 (NQO1) is an enzyme that in humans is encoded by the NQO1 gene.