Most notably, mutations in WNK4 cause the Mendelian disease Familial hyperkalemia and hypertension (FHHt), which results in a hyperactive NCC and clinically presents with hypercalciuria and low bone mineral density in addition to hypertension, hyperkalemia, and metabolic acidosis (Mayan et al. 2002). This evidence concerns the gene WNK4 and Hyperkalemia.