AKT1 and seminoma: In our model, we hypothesized that H19 long non‐coding RNA promotes the expression of TDRG1 by sequestering miRNA‐106b‐5p.39 In turn, up‐regulated TDRG1 promotes resistance to CDDP through PI3K/Akt/mTOR signalling and the mitochondria‐mediated apoptotic pathway.32 In the present study, we aimed to investigate whether TDRG1 protein regulates autophagy and chemosensitivity to CDDP in seminoma cells.