(Table 3) Univariate logistic regression investigation specified that the significant variables for lymph node metastasis were UPP1 expression (odds ratio [OR] 3.28, 95% CI 2.159‐4.985, P < .001), clinical stage (OR 3.555, 95% CI 2.356‐5.366, P < .001), gender (OR 0.653, 95% CI 0.430‐0.992, P = .046) and tumour size (OR 2.672, 95% CI 1.809‐3.947, P < .001), (Table 4). This evidence concerns the gene UPP1 and neoplasm.