Multivariate logistic analysis revealed that UPP1 expression (OR = 3.053, 95% CI 1.957‐4.762, P < .001), clinical stage (OR = 5.117, 95% CI 3.110‐8.419, P < .001) and age (OR = 0.328, 95% CI 0.185‐0.582, P < .001) were associated with lymph node metastasis. Here, UPP1 is linked to metastatic malignant neoplasm in the lymph nodes.