Previous absolute PCa risk estimates by ages 65–80 yr range from 3% to 9% for BRCA1 carriers [7], [17], [21] and from 15% to 34% for BRCA2 carriers [4], [6], [7], [13], [15], [22] (Supplementary Table 2). The gene discussed is BRCA2; the disease is posterior cortical atrophy.