BRCA1 and posterior cortical atrophy: In a prospective cohort of 62 carriers from the USA, BRCA2 mutations were associated with higher PCa risk (SIR 4.89, 95% CI 1.96–10.08) but there was no significant association for BRCA1 carriers (SIR 3.81, 95% CI 0.77–11.13) [12].