In line with previous studies [3], [5], [7], [8], [9], [10], [12], [13], [16], [17], [18], [19], [20], [21], our findings indicate that BRCA1 mutations are at most associated with a moderate PCa risk at younger ages, with RR estimates in the range 2–4 for ages <65 yr. The gene discussed is BRCA1; the disease is posterior cortical atrophy.