By age 85 yr, the absolute risk was 12% (95% CI 5.0–23%) for GS ≤ 6 and 16% (95% CI 6.4–30%) for GS ≥ 7 PCa among BRCA1 carriers, and 9.3% (95% CI 2.9–20%) for GS ≤ 6 and 51% (95% CI 30%-69%) for GS ≥ 7 PCa among BRCA2 carriers. The gene discussed is BRCA1; the disease is posterior cortical atrophy.