PIEZO1 and anemia (phenotype): Furthermore, gain-of-function (GOF) mutations in human Piezo1 cause hereditary xerocytosis (also known as dehydrated stomatocytosis), a familial anemia (Bae et al. 2013; Gottlieb and Sachs 2012), whereas loss-of-function (LOF) mutations cause generalized lymphatic dysplasia characterized by varying degrees of anemia (Fotiou et al. 2015; Lukacs et al. 2015).