ELISPOT assays showed that five mixtures of MHC II-restricted huCD20-derived peptides (huMHC II_Mix 1, huMHC II_Mix 2, huMHC II_Mix 4, huMHC II_Mix 5, and huMHC II_Mix 8) were able to stimulate IFN-γ production by CD4+ T cells isolated from mice injected with EL4-huCD20 tumor cells (Fig. 2). Here, CD4 is linked to neoplasm.