In total, 16 autoAbs were selected for validation based on three criteria: (1) significantly increased levels in SLE compared with NC (FC > 2, P < 0.01); (2) being elevated on both IgG and IgM levels and (3) significantly enriched in the top functional pathways associated with cell death/survival, cell cycle, and DNA recombination, replication, and repair function. The gene discussed is CD40LG; the disease is systemic lupus erythematosus.