In the genomic locus covering rs1549293, the chromosomal interactions with FUS and HSD3B7 were observed to form each of 54 kb and 145 kb complexes, suggesting a regulatory role by this SNP to these obesity-associated genes (Figure 2F, Pearson correlation coefficient r is 0.78 and 0.74, respectively) [34], [35]. The gene discussed is HSD3B7; the disease is obesity due to melanocortin 4 receptor deficiency.