Taken together, we proposed that rs1549293 in KAT8 correlated to larger waist circumference in the northern males of the CASPMI cohort via the enhancer region containing this SNP, in which the weaker binding to PU.1 by the T-allele may alter the expression of the obesity-associated genes FUS and HSD3B7. This evidence concerns the gene SPI1 and obesity due to melanocortin 4 receptor deficiency.