Besides significant gene penal, transcriptional SLC27A2, G6PC, MGAM, TRPM3, PKHD1, MYL3, MAPT, SLC22A6, TRHDE, TMEM174, SLC22A8, OGDHL, SCGN, SLC51B, SLC22A12, REN, PAH, GABRG1, SLC13A2, SST, KCNJ11, TUBB4A and RGS7 expression significantly predicted overall survival for ccRCC patients. The gene discussed is REN; the disease is nonpapillary renal cell carcinoma.