Kaplan-Meier method indicated that decreased AGPAT9, AQP7, HMGCS2, KLF15, PPARGC1A mRNA expression significantly correlated with poor OS (p<0.001), and elevated MLXIPL mRNA expression was significantly associated with shorter OS for ccRCC patients (p=0.012). This evidence concerns the gene HMGCS2 and nonpapillary renal cell carcinoma.