To establish the appropriateness and reliability of employing AREG/IL‐8 for in vivo SASP measurement, we selectively acquired stromal cells from the primary tissues of PCa patients via LCM, and analyzed the expression of a subset of signature SASP factors, including but not limited to MMP1, CXCL3, IL‐1β, WNT16B, IL‐6, and GM‐CSF (Figure S8d). Here, MMP1 is linked to posterior cortical atrophy.