CD274 and colorectal cancer: However, a recent study addressing the impact of chemotherapy on the PD‐1/PD‐L1 pathway revealed that 5‐fluorouracil/oxaliplatin (Folfox) induced complete and long‐term responses in colorectal cancer mice upon combination with anti‐PD‐1 treatment, while each monotherapy failed (Dosset et al., 2018).