Of note, multiple genes hitherto known to be associated with prostate cancer progression were observed in the top list of upregulated entities including but not limited to MYBL2, ESM1, PBK, and UBE2C in PC3, and MMP1, CCL5, and STC1 in DU145 (Figure 4d; Figure S4b). Here, ESM1 is linked to Familial prostate cancer.