Further analysis indicated that MIT induced cleavage of caspase 3 in cancer cells, a process remarkably weakened by AREG but reversible upon elimination of AREG from stromal cells (Figure S3g), implying that AREG drives cancer resistance largely via a caspase‐counteracting mechanism, which dampens caspase 3 activation by its self‐cleavage. Here, CASP3 is linked to cancer.