Interestingly, some of the SASP factors such as IL‐6 and MMP10, together with the typical senescence markers including p16INK4a, were co‐expressed in stromal and cancer epithelial cells, suggesting drug treatment induced comprehensive in vivo cellular senescence, although the SASP profile seemed to develop differently between stromal and cancer cells (Figure 5c; Figure S5c). This evidence concerns the gene CDKN2A and cancer.