AREG and neoplasm: Although some SASP components are cytokines or chemokines per se, such as IL‐8 and CXCL3, diverse growth factors including amphiregulin (AREG) are produced by senescent human stromal cells (Coppe et al., 2008; Sun et al., 2012), suggesting that the impact of the SASP on tumor progression could be complicated and multidimensional.