Finally, the work investigating the effects of phytosterols/phytostanols supplementation on the change in apolipoproteins, including APOA1 and APOB and its ratio, as well as on markers of inflammation and endothelial dysfunction including oxidized LDL-c, flow-mediated dilatation (FMD) and plasminogen activator inhibitor 1 (PAI-1) showed a significant reduction in apo B by 0.07 g/L (95% CI − 0.07, − 0.04). This evidence concerns the gene SERPINE1 and endothelial dysfunction.