Here we used exosomes from ADSCs in combination with miR-21 overexpression to promote the vascularization of endothelial cells for regenerative purpose and demonstrated that miR-21 induces tumor angiogenesis through targeting PTEN, leading to activate AKT and ERK1/2 signaling pathways, and thereby enhancing HIF-1α and VEGF expression (Fig. 7). This evidence concerns the gene HIF1A and neoplasm.