Considering this, it is likely that the negative energy balance induced by nicotine, which besides anorexia is also based on increased energy expenditure, relays not only on BAT thermogenesis3,4, but also in browning-induced thermogenesis, given that UCP1 in brite/beige adipose tissue mitochondria are functionally thermogenic42. This evidence concerns the gene UCP1 and Anorexia.