PheWAS analysis of these variants confirmed strong associations with obesity-related phenotypes including waist circumference (GPR151, marginal association beta = −0.065, p = 2.5 × 10−8), whole-body fat mass (GPR151, beta = −0.069, p = 1.4 × 10−7), trunk fat mass (GPR151, beta = −0.071, p = 1.5 × 10−7), hip circumference (PDE3B, beta = 0.248, p = 1.8 × 10−11), right leg fat-free mass (PDE3B, beta = 0.129, p = 4.2 × 10−8) and body weight (PDE3B, beta = 0.177, p = 4.6 × 10−8) (Fig. 4d, Supplementary Fig. 24, Supplementary Tables 3-4). The gene discussed is PDE3B; the disease is obesity due to melanocortin 4 receptor deficiency.