Specifically, the expression and function of PDE3B and GPR151 were evaluated in mouse 3T3-L1 and human Simpson-Golabi-Behmel Syndrome (SGBS) cells, two well-established preadipocyte models used for studying adipocyte differentiation (i.e. adipogenesis) and function36,37. Here, PDE3B is linked to Simpson-Golabi-Behmel syndrome.