APLN and hydrops fetalis: In several rat models of HF, including isoproterenol-induced (Jia et al., 2006); Dahl salt-sensitive hypertensive (Koguchi et al., 2012); two-kidney, one clip hypertensive (Pang et al., 2014); and left anterior descending coronary artery ligation (Berry et al., 2004; Atluri et al., 2007), apelin induced beneficial changes in the disease state.