As shown in Fig. 2c-d, cell proliferation of U251 and LN229 cells with pcDNA3.1-LINC00174 transfection was promoted compared with that of pcDNA3.1 transfected cells (P < 0.001), and pcDNA3.1-LINC00174 also decreased cell apoptosis of glioma cells (P < 0.001). This evidence concerns the gene LINC00174 and central nervous system cancer.